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Target
Reverse transcriptase
Ligand
BDBM93121
Substrate
n/a
Meas. Tech.
HIV-1 Reverse Transcriptase Assay
IC50
3.61e+3± 8e+2 nM
Citation
 Boechat, N; Kover, WB; Bastos, MM; Romeiro, NC; Silva, ASC; Santos, FC; Valverde, AL; Azevedo, MLG; Wollinger, W; Souza, TML; Oliveira de Souza, SL; P. P. de Frugulhetti, IC Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors Medicinal Chemistry Research 15:492-510 (2007)    Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM93121
Synonyms:
3-Hydroxy-2-oxo-3-trifluoromethylindole, 21
Type:
Small molecule
Emp. Form.:
C10H7BrF3NO2
Mol. Mass.:
310.067
SMILES:
CN1C(=O)C(O)(c2cc(Br)ccc12)C(F)(F)F
Structure:
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