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Target
Protein Wnt-3a
Ligand
BDBM89380
Substrate
n/a
IC50
>50000±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89380
Synonyms:
(2R,4S)-4-cyclohexyl-2-(4-hydroxybutoxy)-N-phenyl-3,4-dihydro-2H-pyran-6-carboxamide | (2R,4S)-4-cyclohexyl-2-(4-oxidanylbutoxy)-N-phenyl-3,4-dihydro-2H-pyran-6-carboxamide | MLS000766522 | SMR000441988 | cid_24746741
Type:
Small organic molecule
Emp. Form.:
C22H31NO4
Mol. Mass.:
373.4858
SMILES:
OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc1ccccc1)C1CCCCC1 |c:9|
Structure:
Search PDB for entries with ligand similarity: