Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM79521
Substrate
n/a
EC50
9800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM79521
Synonyms:
MLS000100230 | N-[4-(4-benzoyl-1-piperazinyl)phenyl]-1-benzofuran-2-carboxamide | N-[4-(4-benzoyl-1-piperazinyl)phenyl]-2-benzofurancarboxamide | N-[4-(4-benzoylpiperazin-1-yl)phenyl]-1-benzofuran-2-carboxamide | N-[4-(4-benzoylpiperazino)phenyl]coumarilamide | N-[4-[4-(phenylcarbonyl)piperazin-1-yl]phenyl]-1-benzofuran-2-carboxamide | SMR000082211 | cid_2236635
Type:
Small organic molecule
Emp. Form.:
C26H23N3O3
Mol. Mass.:
425.4791
SMILES:
O=C(Nc1ccc(cc1)N1CCN(CC1)C(=O)c1ccccc1)c1cc2ccccc2o1
Structure:
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