Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95898
Substrate
n/a
EC50
>12500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95898
Synonyms:
1H-benzimidazol-2-yl-[(E)-[5-(4-bromophenyl)-2-furyl]methyleneamino]amine | MLS000332094 | N-(1H-Benzoimidazol-2-yl)-N'-[1-[5-(4-bromo-phenyl)-furan-2-yl]-meth-(E)-ylidene]-hydrazine | N-[(E)-[5-(4-bromophenyl)-2-furanyl]methylideneamino]-1H-benzimidazol-2-amine | N-[(E)-[5-(4-bromophenyl)furan-2-yl]methylideneamino]-1H-benzimidazol-2-amine | SMR000221572 | cid_9634219
Type:
Small organic molecule
Emp. Form.:
C18H13BrN4O
Mol. Mass.:
381.226
SMILES:
Brc1ccc(cc1)-c1ccc(CN=Nc2nc3ccccc3[nH]2)o1 |w:13.14|
Structure:
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