Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95900
Substrate
n/a
EC50
>12500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95900
Synonyms:
2-(3-Chloro-benzylsulfanyl)-3-methoxy-3H-quinazolin-4-one | 2-[(3-chlorobenzyl)thio]-3-methoxy-quinazolin-4-one | 2-[(3-chlorophenyl)methylsulfanyl]-3-methoxy-quinazolin-4-one | 2-[(3-chlorophenyl)methylsulfanyl]-3-methoxyquinazolin-4-one | 2-[(3-chlorophenyl)methylthio]-3-methoxy-4-quinazolinone | MLS000557272 | SMR000148189 | cid_938363
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O2S
Mol. Mass.:
332.805
SMILES:
COn1c(SCc2cccc(Cl)c2)nc2ccccc2c1=O
Structure:
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