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Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95910
Substrate
n/a
EC50
1870±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95910
Synonyms:
(2E)-4,4,4-trifluoro-2-(p-toluidinomethylene)-1-(2-thienyl)butane-1,3-dione | (2E)-4,4,4-trifluoro-2-[(4-methylanilino)methylidene]-1-thiophen-2-ylbutane-1,3-dione | (2E)-4,4,4-tris(fluoranyl)-2-[[(4-methylphenyl)amino]methylidene]-1-thiophen-2-yl-butane-1,3-dione | 4,4,4-Trifluoro-1-thiophen-2-yl-2-(p-tolylamino-methylene)-butane-1,3-dione | MLS000553429 | SMR000176222 | cid_3121251
Type:
Small organic molecule
Emp. Form.:
C16H12F3NO2S
Mol. Mass.:
339.332
SMILES:
Cc1ccc(cc1)N=CC(C(=O)c1cccs1)C(=O)C(F)(F)F |w:7.7|
Structure:
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