Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM98585
Substrate
n/a
Meas. Tech.
Enzyme Assay
Temperature
297.15±0 K
Ki
89±0.0 nM
Citation
 Stuerzebecher, J; Steinmetzer, T; Schweinitz, A Urokinase inhibitors, production and use thereof US Patent  US8476306 Publication Date 7/2/2013 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD87 | Plasminogen activator urokinase | Plaur | U-PAR | UPAR | UPAR_RAT | URKR
Type:
Protein
Mol. Mass.:
35754.96
Organism:
Rattus norvegicus
Description:
P49616
Residue:
328
Sequence:
MGLLRRRLLLLVVVVTTCVPASQGLRCIQCESNQDCLVEECALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNRPRPGARGRPFPRGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSVKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCCNFTQCNGGPVLDLQSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGSGCNRPTGGAPGPGPAHLILIASLLLTLRLWGIPLWT
  
Inhibitor
Name:
BDBM98585
Synonyms:
(2R)-N-[(1S)-2-[(4-carbamimidoylphenyl)methylamino]-1-methyl-2-oxo-ethyl]-2-[(4-cyanophenyl)methylsulfonylamino]-3-hydroxy-propanamide | US8476306, 6.10
Type:
Small organic molecule
Emp. Form.:
C22H26N6O5S
Mol. Mass.:
486.544
SMILES:
C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccc(cc1)C#N)C(=O)NCc1ccc(cc1)C(N)=N
Structure:
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