Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM98604
Substrate
n/a
Meas. Tech.
Enzyme Assay
Temperature
297.15±0 K
Ki
130±0.0 nM
Citation
 Stuerzebecher, J; Steinmetzer, T; Schweinitz, A Urokinase inhibitors, production and use thereof US Patent  US8476306 Publication Date 7/2/2013 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD87 | Plasminogen activator urokinase | Plaur | U-PAR | UPAR | UPAR_RAT | URKR
Type:
Protein
Mol. Mass.:
35754.96
Organism:
Rattus norvegicus
Description:
P49616
Residue:
328
Sequence:
MGLLRRRLLLLVVVVTTCVPASQGLRCIQCESNQDCLVEECALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNRPRPGARGRPFPRGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSVKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCCNFTQCNGGPVLDLQSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGSGCNRPTGGAPGPGPAHLILIASLLLTLRLWGIPLWT
  
Inhibitor
Name:
BDBM98604
Synonyms:
2-[4-[[(1R)-2-[[2-[4-[(3-amino-4-methoxy-benzoyl)amino]anilino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]sulfamoylmethyl]phenyl]acetic acid | US8476306, 13
Type:
Small organic molecule
Emp. Form.:
C22H27N5O7S
Mol. Mass.:
505.544
SMILES:
NC(=N)c1ccc(CNC(=O)CNC(=O)[C@H](CO)NS(=O)(=O)Cc2ccc(CC(O)=O)cc2)cc1
Structure:
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