Reaction Details Report a problem with these data
Target
Bone morphogenetic protein receptor type-1B
Ligand
BDBM280351
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases
IC50
>1000000±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US10030004 Publication Date 7/24/2018 
Target
Name:
Bone morphogenetic protein receptor type-1B
Synonyms:
ALK-6:ALK6 | Activin receptor-like kinase 6 | Acvrlk6 | BMP type-1B receptor | BMPR-1B | BMR1B_MOUSE | Bmpr1b | SKR6 | Serine/threonine-protein kinase receptor R6
Type:
Enzyme
Mol. Mass.:
56951.97
Organism:
Mus musculus (Mouse)
Description:
P36898
Residue:
502
Sequence:
MLLRSSGKLNVGTKKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSESQDIKL
  
Inhibitor
Name:
BDBM280351
Synonyms:
4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-(methane sulfonamido)ethyl]pyridine-3-carboxamide | US10030004, Compound 18 | US10501436, Compound 18 | US11053216, Compound 18 | US11702401, Compound 18
Type:
Small organic molecule
Emp. Form.:
C23H25ClFN5O3S
Mol. Mass.:
505.993
SMILES:
CC(C)c1cnc(cc1Nc1ccncc1C(=O)NCCNS(C)(=O)=O)-c1cc(Cl)ccc1F
Structure:
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