Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM100435
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.4±0.0 nM
Citation
 Hammock, BD; Jones, PD; Morisseau, C; Huang, H; Tsai, H; Gless, Jr., R Conformationally restricted urea inhibitors of soluble epoxide hydrolase US Patent  US8501783 Publication Date 8/6/2013 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM100435
Synonyms:
US8501783, 1701
Type:
Small organic molecule
Emp. Form.:
C17H29N3O3S
Mol. Mass.:
355.495
SMILES:
CS(=O)(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15,13:14:21:17.18.19|
Structure:
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