Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM102459
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
IC50
109±0.0 nM
Citation
 Castro Palomino Laria, JC; Terricabras Belart, E; Erra Sola, M; Navarro Romero, E; Fonquerna Pou, S; Cardus Figueras, A; Lozoya Toribio, ME Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors US Patent  US8536165 Publication Date 9/17/2013 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM102459
Synonyms:
US8536165, 34
Type:
Small organic molecule
Emp. Form.:
C18H14ClN3O2
Mol. Mass.:
339.776
SMILES:
Cc1ccc(Nc2ccc(nc2)-c2ccncc2Cl)c(c1)C(O)=O
Structure:
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