Reaction Details
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Serine/threonine-protein kinase receptor R3
Ligand
BDBM36354
Substrate
n/a
IC50
77.9±0.0 nM
Citation
Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol 8:1291-302 (2013) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_MOUSE | AI115505 | AI427544 | ALK1 | Acvrl1 | Acvrlk1 | Alk-1
Type:
Protein
Mol. Mass.:
56529.91
Organism:
Mus musculus
Description:
n/a
Residue:
502
Sequence:
MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVIH
Inhibitor
Name:
BDBM36354
Synonyms:
4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin- 3-yl)quinoline | DMH1 | US9040694, 1
Type:
Small organic molecule
Emp. Form.:
C24H20N4O
Mol. Mass.:
380.4418
SMILES:
CC(C)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Structure:
