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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2 [393-601]
Ligand
BDBM104065
Substrate
n/a
Meas. Tech.
Kinome Profiling
IC50
1800±0.0 nM
Citation
 Carlson, DA; Franke, AS; Weitzel, DH; Speer, BL; Hughes, PF; Hagerty, L; Fortner, CN; Veal, JM; Barta, TE; Zieba, BJ; Somlyo, AV; Sutherland, C; Deng, JT; Walsh, MP; Macdonald, JA; Haystead, TA Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor. ACS Chem Biol 8:2715-23 (2013) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 [393-601]
Synonyms:
DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2)
Type:
Protein
Mol. Mass.:
22899.89
Organism:
Homo sapiens (Human)
Description:
Q92630[393-601]
Residue:
209
Sequence:
VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
  
Inhibitor
Name:
BDBM104065
Synonyms:
HS38
Type:
Small organic molecule
Emp. Form.:
C14H12ClN5O2S
Mol. Mass.:
349.795
SMILES:
CC(Sc1nc2n(ncc2c(=O)[nH]1)-c1cccc(Cl)c1)C(N)=O
Structure:
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