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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM106791
Substrate
n/a
Meas. Tech.
PTP activity assay
pH
6±n/a
Temperature
310.15±n/a K
IC50
1.87e+4±n/a nM
Comments
extracted
Citation
 Ma, Y; Sun, SX; Cheng, XC; Wang, SQ; Dong, WL; Wang, RL; Xu, WR Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase. Chem Biol Drug Des 82:595-602 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM106791
Synonyms:
(5Z)‐5‐({2‐[(2,4‐ dichlorophenyl)methoxy]phenyl}methylidene)imidazolidine‐ 2,4‐dione (comp#c)
Type:
Small organic molecule
Emp. Form.:
C17H12Cl2N2O3
Mol. Mass.:
363.195
SMILES:
Clc1ccc(COc2ccccc2\C=C2/NC(=O)NC2=O)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: