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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM106928
Substrate
n/a
Meas. Tech.
ATP Depletion Assay
pH
7.5±0
IC50
1±n/a nM
Citation
 Burger, MT; Han, W; Lan, J; Nishiguchi, G Kinase inhibitors and methods of their use US Patent  US8592455 Publication Date 11/26/2013 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM106928
Synonyms:
US8592455, 128
Type:
Small organic molecule
Emp. Form.:
C24H23F3N4O2
Mol. Mass.:
456.4602
SMILES:
C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(O)cc1F |r,wU:6.8,3.3,1.0,(-.67,1.93,;-2,1.15,;-3.33,1.93,;-4.67,1.15,;-6,1.93,;-4.67,-.38,;-3.33,-1.15,;-2,-.38,;-3.33,-2.69,;-4.67,-3.47,;-4.67,-5,;-3.33,-5.78,;-2,-5,;-2,-3.47,;-.67,-2.69,;.67,-3.47,;.67,-5,;2,-2.69,;3.33,-3.46,;4.67,-2.69,;4.67,-1.15,;6,-.38,;3.33,-.38,;2,-1.15,;3.33,1.15,;2,1.93,;.67,1.15,;2,3.47,;3.33,4.23,;3.33,5.78,;4.67,3.47,;4.67,1.93,;6,1.15,)|
Structure:
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