Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM109238
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
8.3±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109238
Synonyms:
US8609710, 2
Type:
Small organic molecule
Emp. Form.:
C16H27N3O2
Mol. Mass.:
293.4045
SMILES:
C[C@H]1CC[C@@H](CC1)n1cnc(CC(CCCN)C(O)=O)c1 |r,wU:4.7,wD:1.0,(-3.85,5.14,;-3.45,3.65,;-4.54,2.56,;-4.14,1.07,;-2.66,.68,;-1.57,1.76,;-1.97,3.25,;-2.26,-.81,;-3.16,-2.06,;-2.26,-3.3,;-.79,-2.83,;.54,-3.6,;1.87,-2.83,;1.87,-1.29,;3.21,-.52,;3.21,1.02,;4.54,1.79,;3.21,-3.6,;3.21,-5.14,;4.54,-2.83,;-.79,-1.29,)|
Structure:
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