Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM110191
Substrate
n/a
Meas. Tech.
Cathepsin L Inhibition Assay
pH
5.5±n/a
Temperature
310.15±n/a K
IC50
2.80e+3± 100 nM
Comments
extracted
Citation
 Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem 51:24-30 (2013) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM110191
Synonyms:
3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone (13)
Type:
Small organic molecule
Emp. Form.:
C13H10O3S
Mol. Mass.:
246.282
SMILES:
Oc1ccc(\C=C\C(=O)c2cccs2)c(O)c1
Structure:
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