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Target
Breakpoint cluster region protein [1-693]
Ligand
BDBM111454
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
1069±n/a nM
Citation
 Pan, X; Dong, J; Gao, H; Wang, F; Zhang, Y; Wang, S; Zhang, J Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chem Biol Drug Des 83:592-9 (2014) [PubMed]  Article 
Target
Name:
Breakpoint cluster region protein [1-693]
Synonyms:
BCR | BCR1 | BCR_HUMAN | Bcr-Abl | D22S11
Type:
Protein
Mol. Mass.:
76683.66
Organism:
Homo sapiens (Human)
Description:
P11274[1-693]
Residue:
693
Sequence:
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEIT
  
Inhibitor
Name:
BDBM111454
Synonyms:
N-(3-fluorophenyl)-4-methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino) benzamide (A7)
Type:
Small organic molecule
Emp. Form.:
C23H18FN5O
Mol. Mass.:
399.4203
SMILES:
Cc1ccc(cc1Nc1nccc(n1)-c1cccnc1)C(=O)Nc1cccc(F)c1
Structure:
Search PDB for entries with ligand similarity: