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Target
Breakpoint cluster region protein [1-693]
Ligand
BDBM111457
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
1105±n/a nM
Citation
 Pan, X; Dong, J; Gao, H; Wang, F; Zhang, Y; Wang, S; Zhang, J Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chem Biol Drug Des 83:592-9 (2014) [PubMed]  Article 
Target
Name:
Breakpoint cluster region protein [1-693]
Synonyms:
BCR | BCR1 | BCR_HUMAN | Bcr-Abl | D22S11
Type:
Protein
Mol. Mass.:
76683.66
Organism:
Homo sapiens (Human)
Description:
P11274[1-693]
Residue:
693
Sequence:
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEIT
  
Inhibitor
Name:
BDBM111457
Synonyms:
4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-N-p-tolyl benzamide (A10)
Type:
Small organic molecule
Emp. Form.:
C24H21N5O
Mol. Mass.:
395.4564
SMILES:
Cc1ccc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc1
Structure:
Search PDB for entries with ligand similarity: