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Target
Major prion protein
Ligand
BDBM42605
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1005±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM42605
Synonyms:
MLS000073796 | N-(5-Methyl-isoxazol-3-yl)-2-(2-propyl-quinazolin-4-ylsulfanyl)-acetamide | N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanyl-ethanamide | N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanylacetamide | N-(5-methyl-3-isoxazolyl)-2-[(2-propyl-4-quinazolinyl)thio]acetamide | N-(5-methylisoxazol-3-yl)-2-[(2-propylquinazolin-4-yl)thio]acetamide | SMR000006835 | cid_653552
Type:
Small organic molecule
Emp. Form.:
C17H18N4O2S
Mol. Mass.:
342.415
SMILES:
CCCc1nc(SCC(=O)Nc2cc(C)on2)c2ccccc2n1
Structure:
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