Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114319
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1876±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114319
Synonyms:
MLS000555430 | SMR000147147 | Sodium; 2-(quinolin-2-ylsulfanyl)-propionate | cid_23663723 | sodium;2-(2-quinolinylthio)propanoate | sodium;2-(2-quinolylthio)propionate | sodium;2-quinolin-2-ylsulfanylpropanoate
Type:
Small organic molecule
Emp. Form.:
C12H10NO2S
Mol. Mass.:
232.279
SMILES:
CC(Sc1ccc2ccccc2n1)C([O-])=O
Structure:
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