Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114331
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1843±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114331
Synonyms:
2-(2-Ethyl-quinazolin-4-ylsulfanyl)-1-phenothiazin-10-yl-ethanone | 2-(2-ethylquinazolin-4-yl)sulfanyl-1-phenothiazin-10-yl-ethanone | 2-(2-ethylquinazolin-4-yl)sulfanyl-1-phenothiazin-10-ylethanone | 2-[(2-ethyl-4-quinazolinyl)thio]-1-(10-phenothiazinyl)ethanone | 2-[(2-ethylquinazolin-4-yl)thio]-1-phenothiazin-10-yl-ethanone | MLS000555763 | SMR000172945 | cid_1435033
Type:
Small organic molecule
Emp. Form.:
C24H19N3OS2
Mol. Mass.:
429.557
SMILES:
CCc1nc(SCC(=O)N2c3ccccc3Sc3ccccc23)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: