Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM47306
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
875.59±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM47306
Synonyms:
2-[(5-cyano-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)ethanamide | 2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)acetamide | 2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)thio]-N-(methylcarbamoyl)acetamide | 2-[[5-cyano-4-keto-6-(2-thienyl)-1H-pyrimidin-2-yl]thio]-N-(methylcarbamoyl)acetamide | MLS000705748 | N-({[5-cyano-6-oxo-4-(2-thienyl)-1,6-dihydro-2-pyrimidinyl]sulfanyl}acetyl)-N'-methylurea | SMR000231787 | cid_1817440
Type:
Small organic molecule
Emp. Form.:
C13H11N5O3S2
Mol. Mass.:
349.388
SMILES:
CNC(=O)NC(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: