Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114384
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1835±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114384
Synonyms:
2-[(2-phenyl-4-quinazolinyl)thio]propanoic acid ethyl ester | 2-[(2-phenylquinazolin-4-yl)thio]propionic acid ethyl ester | MLS000687054 | SMR000284159 | cid_3167727 | ethyl 2-(2-phenylquinazolin-4-yl)sulfanylpropanoate
Type:
Small organic molecule
Emp. Form.:
C19H18N2O2S
Mol. Mass.:
338.423
SMILES:
CCOC(=O)C(C)Sc1nc(nc2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: