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Target
Major prion protein
Ligand
BDBM78382
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1441±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM78382
Synonyms:
6-bromo-5-hydroxy-2-phenyl-3-benzofurancarboxylic acid ethyl ester | 6-bromo-5-hydroxy-2-phenyl-benzofuran-3-carboxylic acid ethyl ester | MLS001197117 | SMR000555502 | cid_979431 | ethyl 6-bromanyl-5-oxidanyl-2-phenyl-1-benzofuran-3-carboxylate | ethyl 6-bromo-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H13BrO4
Mol. Mass.:
361.187
SMILES:
CCOC(=O)c1c(oc2cc(Br)c(O)cc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: