Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM66192
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1410±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM66192
Synonyms:
6-bromanyl-2-thiophen-2-yl-quinoline-4-carboxylic acid | 6-bromo-2-(2-thienyl)cinchoninic acid | 6-bromo-2-thiophen-2-yl-4-quinolinecarboxylic acid | 6-bromo-2-thiophen-2-ylquinoline-4-carboxylic acid | MLS001182077 | SMR000567820 | cid_755656
Type:
Small organic molecule
Emp. Form.:
C14H8BrNO2S
Mol. Mass.:
334.188
SMILES:
OC(=O)c1cc(nc2ccc(Br)cc12)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: