Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114430
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
2046±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114430
Synonyms:
2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(4-methyl-thiazol-2-yl)-acetamide | 2-[(2-isopropylquinazolin-4-yl)thio]-N-(4-methylthiazol-2-yl)acetamide | MLS001221905 | N-(4-methyl-1,3-thiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide | N-(4-methyl-1,3-thiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide | N-(4-methyl-2-thiazolyl)-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide | SMR000601897 | cid_1442810
Type:
Small organic molecule
Emp. Form.:
C17H18N4OS2
Mol. Mass.:
358.481
SMILES:
CC(C)c1nc(SCC(=O)Nc2nc(C)cs2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: