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Target
Oxysterols receptor LXR-beta
Ligand
BDBM114835
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).
IC50
67513±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM114835
Synonyms:
4-[[2-(4-methylphenyl)-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl ester | 4-[[3,4-diketo-2-(p-tolyl)cyclobuten-1-yl]amino]piperidine-1-carboxylic acid ethyl ester | MLS000094572 | SMR000030123 | cid_3238133 | ethyl 4-[[2-(4-methylphenyl)-3,4-bis(oxidanylidene)cyclobuten-1-yl]amino]piperidine-1-carboxylate | ethyl 4-[[2-(4-methylphenyl)-3,4-dioxocyclobuten-1-yl]amino]piperidine-1-carboxylate | ethyl 4-{[2-(4-methylphenyl)-3,4-dioxocyclobut-1-en-1-yl]amino}piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H22N2O4
Mol. Mass.:
342.389
SMILES:
CCOC(=O)N1CCC(CC1)Nc1c(-c2ccc(C)cc2)c(=O)c1=O
Structure:
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