Reaction Details Report a problem with these data
Target
Urea transporter 2
Ligand
BDBM50322180
Substrate
n/a
Meas. Tech.
UT-A1 Inhibition Assay
IC50
3.8e+3±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 2
Synonyms:
Slc14a2 | UT2_RAT | Urea transporter 2 | Urea transporter A1 (UT-A1) | Ut2
Type:
Protein
Mol. Mass.:
101906.19
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
929
Sequence:
MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETVFPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTYPEANRIYFLSQEKNRRASMITKYQAYDVS
  
Inhibitor
Name:
BDBM50322180
Synonyms:
3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine | CHEMBL1172794 | UT-A1 inhibitor D1
Type:
Small organic molecule
Emp. Form.:
C18H19N5O2S2
Mol. Mass.:
401.506
SMILES:
CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C
Structure:
Search PDB for entries with ligand similarity: