Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM118176
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.71±n/a nM
Comments
extracted
Citation
 Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent  US8653125 Publication Date 2/18/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM118176
Synonyms:
US8653125, Ia-30
Type:
Small organic molecule
Emp. Form.:
C23H22FN3O3
Mol. Mass.:
407.4375
SMILES:
Fc1ccccc1-c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)NC(=O)c2ccon2)cc1 |r,wU:17.21,14.14,(8.52,-.24,;8.52,-1.78,;9.85,-2.55,;9.85,-4.09,;8.52,-4.86,;7.19,-4.09,;7.19,-2.55,;5.85,-1.78,;4.52,-2.55,;3.19,-1.78,;3.19,-.24,;1.85,.53,;.52,-.24,;.52,-1.78,;-.82,.53,;-.82,2.07,;-2.15,2.84,;-3.48,2.07,;-3.48,.53,;-2.15,-.24,;-4.82,2.84,;-6.15,2.07,;-6.15,.53,;-7.48,2.84,;-8.95,2.37,;-9.85,3.61,;-8.95,4.86,;-7.48,4.38,;4.52,.53,;5.85,-.24,)|
Structure:
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