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Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
Ligand
BDBM119072
Substrate
n/a
IC50
1.204e+4±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
Synonyms:
MURA2_STAAM | MurA (S. aureus) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | murA2 | murZ
Type:
Protein
Mol. Mass.:
45068.88
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurA
Residue:
419
Sequence:
MAQEVIKIRGGRTLNGEVNISGAKNSAVAIIPATLLAQGHVKLEGLPQISDVKTLVSLLEDLNIKASLNGTELEVDTTEIQNAALPNNKVESLRASYYMMGAMLGRFKKCVIGLPGGCPLGPRPIDQHIKGFKALGAEIDESSTTSMKIEAKELKGAHIFLDMVSVGATINIMLAAVYATGQTVIENAAKEPEVVDVANFLTSMGANIKGAGTSTIKINGVKELHGSEYQVIPDRIEAGTYMCIAAACGENVILNNIVPKHVETLTAKFSELGVNVDVRDERIRINNNAPYQFVDIKTLVYPGFATDLQQPITPLLFMANGPSFVTDTIYPERFKHVEELKRMGANIEVDEGTATIKPSTLHGAEVYASDLRAGACLIIAGLIAEGVTTIYNVKHIYRGYTDIVEHLKALGADIWTETV
  
Inhibitor
Name:
BDBM119072
Synonyms:
MurA inhibitor (compound 8)
Type:
Small organic molecule
Emp. Form.:
C15H20N2O
Mol. Mass.:
244.3321
SMILES:
CN1CCN(CC1)C1CCc2ccccc2C1=O
Structure:
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