Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM119732
Substrate
n/a
Meas. Tech.
Fluorescence-polarization Binding Assay
pH
7.5±n/a
IC50
18±n/a nM
Comments
extracted
Citation
 Wang, S; Sun, W Spiro-oxindole MDM2 antagonists US Patent  US8680132 Publication Date 3/25/2014 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM119732
Synonyms:
US8680132, C03401 | US9079913, C03401
Type:
Small organic molecule
Emp. Form.:
C28H33Cl2N3O3
Mol. Mass.:
530.486
SMILES:
CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1 |r,wU:16.18,8.8,5.4,30.33,32.37,wD:7.30,32.36,(4.92,-2.42,;3.83,-1.33,;4.23,.16,;5.32,-.93,;2.34,-1.73,;1.25,-.64,;1.25,.9,;-.21,1.38,;-1.12,.13,;-2.6,.53,;-3.69,-.56,;-5.18,-.16,;-5.58,1.33,;-4.49,2.41,;-4.89,3.9,;-3,2.02,;-.21,-1.12,;.69,-2.36,;2.18,-2.76,;-.21,-3.61,;-1.68,-3.13,;-3.01,-3.9,;-4.34,-3.13,;-5.68,-3.9,;-4.34,-1.59,;-3.01,-.82,;-1.68,-1.59,;-.21,2.92,;-1.54,3.69,;1.12,3.69,;2.46,2.92,;3.94,3.31,;4.34,1.83,;5.68,2.6,;5.68,1.06,;2.86,1.43,)|
Structure:
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