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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM119736
Substrate
n/a
Meas. Tech.
Fluorescence-polarization Binding Assay
pH
7.5±n/a
IC50
8±n/a nM
Comments
extracted
Citation
 Wang, S; Sun, W Spiro-oxindole MDM2 antagonists US Patent  US8680132 Publication Date 3/25/2014 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM119736
Synonyms:
US8680132, C09101 | US9079913, C091
Type:
Small organic molecule
Emp. Form.:
C30H36Cl2FN3O3
Mol. Mass.:
576.53
SMILES:
CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NC1CC[C@@](C)(O)CC1 |r,wU:17.19,8.8,5.4,34.39,wD:7.31,34.38,(4.54,-2.79,;3.45,-1.7,;3.85,-.21,;4.94,-1.3,;1.97,-2.1,;.88,-1.01,;.88,.53,;-.59,1.01,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;-.59,-1.49,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,;-.99,2.49,;-2.47,2.89,;.1,3.58,;1.59,3.18,;2.68,4.27,;4.17,3.87,;4.57,2.39,;5.65,3.47,;6.05,1.99,;3.48,1.3,;1.99,1.7,)|
Structure:
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