Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM123162
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.8±n/a
IC50
6.242±n/a nM
Comments
extracted
Citation
 Duffy, JL; Bao, J; Ondeyka, DL; Tyagarajan, S; Shao, P; Ye, F; Katipally, R; Zwicker, A; Sherer, EC; Plotkin, MA; Moningka, R; Hussain, Z; Wood, HB; Ujjainwalla, F; Romero, FA; Finke, PE; Zang, Y; Liu, W Spiroxazolidinone compounds US Patent  US8742110 Publication Date 6/3/2014 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM123162
Synonyms:
US8742110, 1-11
Type:
Small organic molecule
Emp. Form.:
C29H31ClF2N4O4
Mol. Mass.:
573.031
SMILES:
Cc1cc(ccc1C(O)=O)N1CC2(CCN(Cc3cn(nc3-c3cc(F)c(Cl)cc3F)C(C)(C)C)CC2)OC1=O
Structure:
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