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Target
Histone deacetylase 1
Ligand
BDBM124188
Substrate
n/a
Meas. Tech.
Activity Assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
>30000±n/a nM
Comments
extracted
Citation
 Kozikowski, A; Butler, KV; Kalin, JH HDAC inhibitors and therapeutic methods of using same US Patent  US8748451 Publication Date 6/10/2014 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM124188
Synonyms:
US8748451, 3 | US8748451, 7
Type:
n/a
Emp. Form.:
C18H25N3O2
Mol. Mass.:
315.41
SMILES:
CN1CCc2c(C1)n(CCCCCC(=O)NO)c1ccccc21
Structure:
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