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Target
Prostaglandin D2 receptor 2
Ligand
BDBM127133
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
23.9±n/a nM
Comments
extracted
Citation
 Oost, T; Anderskewitz, R; Hamprecht, DW; Hoenke, C; Martyres, D; Rist, W; Seither, P Pyrazole compounds as CRTH2 antagonists US Patent  US8791272 Publication Date 7/29/2014 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM127133
Synonyms:
US8791272, 2.16
Type:
Small organic molecule
Emp. Form.:
C24H30F3N3O3
Mol. Mass.:
465.5085
SMILES:
CCc1nn(Cc2ccc(NC(=O)C3CCC(CC3)C(F)(F)F)cc2)c(CC)c1CC(O)=O |(-9.77,.07,;-8.43,.84,;-7.1,.07,;-7.1,-1.47,;-5.63,-1.95,;-4.86,-3.28,;-3.32,-3.28,;-2.55,-4.62,;-1.01,-4.62,;-.24,-3.28,;1.3,-3.28,;2.07,-1.95,;1.3,-.61,;3.61,-1.95,;4.38,-3.28,;5.92,-3.28,;6.69,-1.95,;5.92,-.61,;4.38,-.61,;8.23,-1.95,;9.77,-1.95,;8.23,-3.49,;8.23,-.41,;-1.01,-1.95,;-2.55,-1.95,;-4.73,-.7,;-3.19,-.7,;-2.42,.63,;-5.63,.54,;-5.08,1.98,;-6.05,3.18,;-5.5,4.62,;-7.57,2.94,)|
Structure:
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