Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50105676
Substrate
n/a
Meas. Tech.
Inhibition of Histone Deacetylase Enzymatic Assay
Temperature
310.15±n/a K
IC50
>25000±n/a nM
Comments
extracted
Citation
 Déziel, R; Ajamian, A Inhibitors of histone deacetylase and prodrugs thereof US Patent  US8796330 Publication Date 8/5/2014 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50105676
Synonyms:
2-(4-Benzenesulfonylamino-benzyl)-N-hydroxy-3-methyl-butyramide | CHEMBL97632 | US8796330, 81
Type:
Small organic molecule
Emp. Form.:
C18H22N2O4S
Mol. Mass.:
362.443
SMILES:
CC(C)C(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Structure:
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