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Target
Epoxide hydrolase 1
Ligand
BDBM129303
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
110±n/a nM
Citation
 Hammock, BD; Zheng, J; Morisseau, C; Motoba, K; Moghaddam, MF; Borhan, B; Grant, DF; Greene, J; Sisemore, MF; Sanborn, J Inhibitors of epoxide hydrolases for the treatment of inflammation US Patent  US8815951 Publication Date 8/26/2014 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM129303
Synonyms:
US8815951, 65
Type:
Small organic molecule
Emp. Form.:
C13H17BrN2O
Mol. Mass.:
297.191
SMILES:
Brc1ccc(NC(=O)NC2CCCCC2)cc1
Structure:
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