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Target
Fibroblast growth factor receptor 3
Ligand
BDBM130084
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
Temperature
298.15±n/a K
IC50
10±n/a nM
Comments
extracted
Citation
 Furet, P; Graus Porta, D; Guagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent  US8815901 Publication Date 8/26/2014 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM130084
Synonyms:
US8815901, 177
Type:
Small organic molecule
Emp. Form.:
C24H23ClFN5O3
Mol. Mass.:
483.923
SMILES:
COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN(C)C)[nH]2)c2ncccc12 |(7.33,3.93,;8.1,2.59,;7.33,1.26,;8.1,-.08,;7.33,-1.41,;8.1,-2.74,;9.64,-2.74,;5.79,-1.41,;5.02,-2.74,;5.02,-.08,;5.79,1.26,;5.02,2.59,;3.48,-.08,;2.71,1.26,;1.17,1.26,;.4,-.08,;-1.14,-.08,;-1.91,1.26,;-1.91,-1.41,;-3.44,-1.41,;-4.34,-.16,;-5.81,-.64,;-5.81,-2.18,;-7.14,-2.95,;-8.48,-2.18,;-9.81,-2.95,;-8.48,-.64,;-4.34,-2.65,;1.17,-1.41,;.4,-2.74,;1.17,-4.08,;2.71,-4.08,;3.48,-2.74,;2.71,-1.41,)|
Structure:
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