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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Ligand
BDBM137916
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
51±n/a nM
Comments
extracted
Citation
 Motomura, T; Nagamori, H; Suzawa, K; Ito, H; Morita, T; Kobayashi, S; Shinkai, H Fluorene compound and pharmaceutical use thereof US Patent  US8871934 Publication Date 10/28/2014 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Synonyms:
PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2)
Type:
Enzyme
Mol. Mass.:
46153.78
Organism:
Homo sapiens (Human)
Description:
Q15119
Residue:
407
Sequence:
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
  
Inhibitor
Name:
BDBM137916
Synonyms:
US8871934, 509
Type:
Small organic molecule
Emp. Form.:
C31H33F3N2O3
Mol. Mass.:
538.6005
SMILES:
OCCn1cc(cn1)-c1cc(OCCC23CC4CC(CC(C4)C2)C3)cc2c1-c1ccccc1C2(O)C(F)(F)F |TLB:23:14:21:17.18.19,THB:22:14:17:21.20.19,22:20:17:14.23.15,13:14:21:17.18.19,23:18:21:14.22.15|
Structure:
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