Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM138359
Substrate
n/a
Meas. Tech.
FP Assay
IC50
329.1±n/a nM
Citation
 Graef, IA; Alhamadsheh, M Identification of stabilizers of multimeric proteins US Patent  US8877795 Publication Date 11/4/2014 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138359
Synonyms:
US10278929, Compound 9 | US11337935, Compound 9 | US8877795, 9
Type:
Small organic molecule
Emp. Form.:
C15H13N3O2
Mol. Mass.:
267.2826
SMILES:
CCOc1ccccc1-c1nc(no1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: