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Target
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Ligand
BDBM285726
Substrate
n/a
Meas. Tech.
Calcineurin Phosphatase (CaN) Assay
IC50
327±n/a nM
Citation
 Pettit, SN; Jones, AD; Frydrych, CS; Thomas, AJ; Garst, ME Cyclosporins modified on the MeBmt sidechain by heterocyclic rings US Patent  US10077289 Publication Date 9/18/2018 
Target
Name:
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Synonyms:
CALNA3 | CAM-PRP catalytic subunit | CNA3 | Calcineurin, testis-specific catalytic subunit | Calmodulin-dependent calcineurin A subunit gamma isoform | PP2BC_HUMAN | PPP3CC
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58133.25
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
512
Sequence:
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
  
Inhibitor
Name:
BDBM285726
Synonyms:
US10077289, Compound 34 | [2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrid-2-yl)heptanoic acid]1[(R)-hydroxymethyl Sar]3 cyclosporin A
Type:
Small organic molecule
Emp. Form.:
C67H116N12O13
Mol. Mass.:
1297.7105
SMILES:
CC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)CCCc2ccccn2)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CO)N(C)C1=O)C(C)C |r|
Structure:
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