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Target
Interleukin-6
Ligand
BDBM140020
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Ligand Binding Assay
IC50
291±n/a nM
Citation
 Rucker, PV; Snyder, JS Tricyclic compounds, compositions, and methods US Patent  US8901310 Publication Date 12/2/2014 
Target
Name:
Interleukin-6
Synonyms:
B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | IL6_HUMAN | Interferon beta-2
Type:
n/a
Mol. Mass.:
23717.96
Organism:
Homo sapiens (Human)
Description:
P05231
Residue:
212
Sequence:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  
Inhibitor
Name:
BDBM140020
Synonyms:
US8901310, Comparator J
Type:
Small organic molecule
Emp. Form.:
C31H34F3N3O2
Mol. Mass.:
537.6158
SMILES:
Cc1ncc(NC(=O)c2ccc3c(CC[C@@H]4C[C@@](O)(CCC(F)(F)F)CC[C@@]34Cc3ccccc3)c2)c(C)n1 |r|
Structure:
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