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Target
Interleukin-6
Ligand
BDBM140011
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Ligand Binding Assay
IC50
>36.4±n/a nM
Citation
 Rucker, PV; Snyder, JS Tricyclic compounds, compositions, and methods US Patent  US8901310 Publication Date 12/2/2014 
Target
Name:
Interleukin-6
Synonyms:
B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | IL6_HUMAN | Interferon beta-2
Type:
n/a
Mol. Mass.:
23717.96
Organism:
Homo sapiens (Human)
Description:
P05231
Residue:
212
Sequence:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  
Inhibitor
Name:
BDBM140011
Synonyms:
US8901310, Comparator A
Type:
Small organic molecule
Emp. Form.:
C32H35F3N2O2
Mol. Mass.:
536.6277
SMILES:
Cc1ncccc1CNC(=O)c1ccc2c(CC[C@@H]3C[C@@](O)(CCC(F)(F)F)CC[C@@]23Cc2ccccc2)c1 |r|
Structure:
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