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Target
Sodium/calcium exchanger 1
Ligand
BDBM140617
Substrate
n/a
Meas. Tech.
Reverse Mode Assay
IC50
200±n/a nM
Citation
 Czechtizky, W; Weston, J; Rackelmann, N; Podeschwa, M; Arndt, P; Wirth, K; Goegelein, H; Ritzeler, O; Kraft, V; Bellevergue, P; McCort, G Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals US Patent  US8912224 Publication Date 12/16/2014 
Target
Name:
Sodium/calcium exchanger 1
Synonyms:
CNC | NAC1_HUMAN | NCX1 | SLC8A1 | Sodium/calcium exchanger 1(NCX1)
Type:
Protein
Mol. Mass.:
108507.88
Organism:
Homo sapiens (Human)
Description:
P32418
Residue:
973
Sequence:
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
  
Inhibitor
Name:
BDBM140617
Synonyms:
US8912224, 46
Type:
Small organic molecule
Emp. Form.:
C26H22FN3O3S
Mol. Mass.:
475.535
SMILES:
Fc1cccc(c1)C1CCc2cc(Oc3ncc(CNC(=O)Cc4ccncc4)s3)ccc2O1
Structure:
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