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Target
Sodium/calcium exchanger 1
Ligand
BDBM140912
Substrate
n/a
Meas. Tech.
Reverse Mode Assay
IC50
120±n/a nM
Citation
 Czechtizky, W; Weston, J; Rackelmann, N; Podeschwa, M; Arndt, P; Wirth, K; Goegelein, H; Ritzeler, O; Kraft, V; Bellevergue, P; McCort, G Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals US Patent  US8912224 Publication Date 12/16/2014 
Target
Name:
Sodium/calcium exchanger 1
Synonyms:
CNC | NAC1_HUMAN | NCX1 | SLC8A1 | Sodium/calcium exchanger 1(NCX1)
Type:
Protein
Mol. Mass.:
108507.88
Organism:
Homo sapiens (Human)
Description:
P32418
Residue:
973
Sequence:
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
  
Inhibitor
Name:
BDBM140912
Synonyms:
US8912224, 350
Type:
Small organic molecule
Emp. Form.:
C21H20N2O4S
Mol. Mass.:
396.459
SMILES:
OCCNC(=O)c1csc(Oc2ccc3O[C@@H](CCc3c2)c2ccccc2)n1
Structure:
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