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Target
D(2) dopamine receptor
Ligand
BDBM141774
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
53.71±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzofurane-piperidine compounds US Patent  US8921397 Publication Date 12/30/2014 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM141774
Synonyms:
US8921397, 16
Type:
Small organic molecule
Emp. Form.:
C25H36N2O3
Mol. Mass.:
412.5649
SMILES:
CC(C)(O)C(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2coc3ccccc23)CC1 |r,wU:10.10,wD:7.6,(10.23,1.23,;8.69,1.23,;8.69,2.77,;8.69,-.31,;7.15,1.23,;6.38,2.56,;6.38,-.1,;4.84,-.1,;4.07,1.23,;2.53,1.23,;1.76,-.1,;.22,-.1,;-.55,-1.44,;-2.09,-1.44,;-2.86,-2.77,;-4.4,-2.77,;-5.17,-1.44,;-4.4,-.1,;-2.86,-.1,;-6.71,-1.44,;-7.62,-2.68,;-9.08,-2.21,;-9.08,-.67,;-10.23,.36,;-9.91,1.87,;-8.44,2.35,;-7.3,1.32,;-7.62,-.19,;2.53,-1.44,;4.07,-1.44,)|
Structure:
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