Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha'
Ligand
BDBM142785
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
1.53±n/a nM
Comments
extracted
Citation
 Purandare, AV; Fink, BE; Gavai, AV; Johnson, WL; Hart, AC; He, L; Huynh, TN; Inghrim, J; Mastalerz, H; Sang, X; Tarby, CM; Wan, H; Vaccaro, W; Zhang, G; Zhao, Y; Zimmermann, K Imidazotriazinecarbonitriles useful as kinase inhibitors US Patent  US8940736 Publication Date 1/27/2015 
Target
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM142785
Synonyms:
US8940736, 119
Type:
Small organic molecule
Emp. Form.:
C26H26ClN11
Mol. Mass.:
528.011
SMILES:
Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)NC1CC(C1)C#N)C#N |(.17,-2.05,;1.5,-2.82,;1.5,-4.36,;.17,-5.13,;-1.16,-4.36,;-1.16,-2.82,;-2.5,-2.05,;-2.5,-.51,;-1.16,.26,;-.39,1.59,;.38,.26,;-3.83,-2.82,;-5.3,-2.35,;-6.2,-3.59,;-5.3,-4.84,;-6.07,-6.17,;-6.84,-7.51,;-3.83,-4.36,;-2.5,-5.13,;2.84,-5.13,;4.17,-4.36,;4.17,-2.82,;2.84,-2.05,;2.84,-.51,;4.17,.26,;4.17,1.8,;2.84,2.57,;1.5,1.8,;1.5,.26,;2.84,4.11,;1.5,4.88,;1.1,6.36,;-.38,5.97,;.01,4.48,;-1.72,6.74,;-3.05,7.51,;5.5,-5.13,;6.84,-5.9,)|
Structure:
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