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Target
Tyrosine-protein kinase receptor
Ligand
BDBM144293
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.24±n/a nM
Citation
 Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent  US8969336 Publication Date 3/3/2015 
Target
Name:
Tyrosine-protein kinase receptor
Synonyms:
EML4 ALK Fusion Protein
Type:
Protein
Mol. Mass.:
87656.33
Organism:
Homo sapiens (Human)
Description:
A9YLN7
Residue:
796
Sequence:
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
  
Inhibitor
Name:
BDBM144293
Synonyms:
US8969336, 377
Type:
Small organic molecule
Emp. Form.:
C25H37N7O2
Mol. Mass.:
467.607
SMILES:
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:27.29,wD:30.33,(4.72,1.95,;4.72,.41,;3.38,-.36,;2,.39,;.67,-.38,;-.1,.95,;.67,2.28,;-1.44,1.72,;.67,-1.92,;-.67,-2.69,;-2,-1.92,;-2,-.38,;-3.33,.39,;-4.67,-.38,;-6,.39,;-6,1.93,;-7.34,2.7,;-8.72,1.95,;-10.05,2.72,;-8.67,.39,;-7.34,-.38,;-4.72,-1.95,;-6.05,-2.72,;-3.33,-2.69,;2,-2.69,;3.33,-1.92,;4.67,-2.69,;6,-1.92,;6,-.38,;7.34,.39,;8.67,-.38,;10,.39,;8.67,-1.92,;7.34,-2.69,)|
Structure:
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