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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM144440
Substrate
n/a
Meas. Tech.
Binding Assay
pH
6±n/a
Temperature
298.15±n/a K
Ki
0.6±n/a nM
Comments
extracted
Citation
 Blouin, M; Burch, J; Han, Y; Mellon, C Thiophenecarboxamide derivatives as EP4 receptor ligands US Patent  US8969394 Publication Date 3/3/2015 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM144440
Synonyms:
US8969394, 14
Type:
Small organic molecule
Emp. Form.:
C25H22F3N5OS
Mol. Mass.:
497.535
SMILES:
Cc1sc(C)c(C(=O)NC2(CC2)c2ccc(cc2)-c2nn[nH]n2)c1Cc1ccc(cc1)C(F)(F)F
Structure:
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